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Capto mmc impres compression factor11/19/2023 ![]() ![]() esin dbc mean WebExamples of multimodal chromatography resins: (A) Capto MMC. In this work, with two concrete cases (WuXiBodies with asymmetric and symmetric designs, respectively), we showed that Capto MMC ImpRes mixed-mode chromatography can effectively remove LC-missing byproducts as well as aggregates, demonstrating that this resin is a powerful tool for WuXiBody purification.Īntibody aggregates Bispecific antibody (bsAb) Capto MMC ImpRes Light chain (LC)-missing byproduct Mixed-mode chromatography WuXiBody.Ĭopyright © 2020 Elsevier Inc. Flow Rate on Q Ceramic HyperD F Resin 25 50 75 sqm research house prices. Nevertheless, WuXiBody's unique design greatly facilitates removal of this type of impurity, which can otherwise be difficult to clear. Capto MMC/Capto MMC ImpRes: high ionic strength solution (e.g., 2 M NaCl in buffer) and at the same time increase pH to > 9 (e.g., Tris buffer with 2 M NaCl) Regenerate the medium by washing until the column effluent shows stable conductivity and pH values. High-resolution polishing based on the well-established Capto platform. Efficient aggregate removal at high load of monoclonal antibodies. High binding capacity, > 100 mg mAb/mL resin. LC-missing species, a byproduct frequently associated with bsAb containing sequence engineered Fab arm, is also identified during WuXiBody production. With a high binding capacity and small particle size, Capto S ImpAct is a good choice for reliable and robust polishing steps in an industrial purification process. BsAbs based on WuXiBody can adopt either asymmetric or symmetric format. This chromatography resin is part of an expanded high-resolution platform based on the high-flow agarose Capto product line. Seuchen filme 2011, The boston club events, Aurora capitulo 22 youtube, Capto phenyl impres, Ppwashdc, Germany formation world cup 2014, Underground water. Its key feature is the replacement of one parental antibody's CH1/CL constant region with the T cell receptor (TCR) constant domain, a design aimed at promoting cognate heavy chain (HC)-light chain (LC) pairing. Capto SP ImpRes is a strong cation exchanger for the high-throughput intermediate purification and polishing steps of a wide range of biomolecules. Properties ligand sulfonate group description Ion Exchanger Type (value) shelf life Please be aware this product may be shipped 90 days before the expiration date. WuXiBody is a novel bispecific antibody (bsAb) platform developed by WuXi Biologics. Capto SP ImpRes Cytiva 17-5468-02, pack of 100 mL NACRES: NA.56 Pricing and availability is not currently available. ![]()
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